Episode: 1 Jennifer Aniston (Series Premiere) Episode: 2 Megan Mullally Episode: 3 Sean Hayes/Nikki Reed Episode: 4 Amanda Bynes/Sharon Stone/Thicke Episode: 5 Jennifer Love Hewitt/John C. McGinley Episode: 6 Peter Boyle/Eve Episode: 7 Terry Bradshaw/Kim Cattrall/Seal Episode: 8 Noah Wyle/Bob Guiney/Elton John Episode: 9 Sean Astin/Breckin Meyer Episode: 10 Richard Simmons/Randy Jackson Episode: 11 Neve Campbell/Ruben Studdard Episode: 12 Merv Griffin/Topher Grace Episode: 13 Jessica Capshaw/The Thrills Episode: 14 Kim Cattrall/Bobby J. Thompson Episode: 15 Betty White/Amy Smart/Gavin DeGraw Episode: 16 Burt Reynolds/Nick Gannon Episode: 17 Ashton Kutcher/Deidre Hall/Travis Episode: 18 Julie Bowen/Fefe Dobson Episode: 19 Amy Brenneman and LeAnn Rimes Episode: 20 Katey Segal/Chris Harrison/Brian McKnight Episode: 21 Seth Green/Tyra Banks Episode: 22 Charlize Theron/Brook Shields Episode: 23 Diane Lane/Missy Elliot Episode: 24 Naomi Watts/Shoshana Johnson/Five For Fighting Episode: 25 Meg Ryan/Jason Lewis/The Indigo Girls Episode: 26 Jessica Simpson / Nick Lachey / Henry Winkler Episode: 27 Sarah Michelle Gellar/Olivier Martinez/Brad Paisley Episode: 28 Ben Affleck/Sara Rue Episode: 34 Katie Holmes, Black Eyed Peas Episode: 41 Season 1 Halloween Show: Ellen as Dr. Phil Episode: 42 Kiefer Sutherland, Jane Leeves Episode: 44 Jeff Bridges, Doris Roberts Episode: 49 Steve Harvey, Rod Stewart Episode: 50 Holly Hunter, Sarah McLachlan, Jeff Corwin Episode: 51 Lauren Graham, Frankie Muniz Episode: 52 Brendan Fraser, John Stamos Episode: 53 Queen Latifah, Sheryl Crow Episode: 54 Eric McCormack, Paul Walker Episode: 55 Jenna Elfman, Cyndi Lauper Episode: 56 Bernie Mac, Valerie Bertinelli Episode: 57 Robert Downey Jr., Mary J. Blige Episode: 58 Bette Midler, Bob Guiney Episode: 134 Dwayne The Rock Johnson, Jami Gertz Episode: 135 David Duchovny, Poppy Montgomery Episode: 136 Anne Hathaway, Cedric the Entertainer Episode: 137 Jessica Simpson & Nick Lachey, Henry Winkler, Hugh Dancy Episode: 138 Elisha Cuthbert, Dennis Franz Episode: 139 Barry Manilow, Nia Vardolas, Baby Birds Episode: 140 Janet Jackson, David Arquette, Ellen's Own Award Show Episode: 141 John Travolta, Goran Visnjic, Random Acts of Kindness Episode: 142 Tina Fey, David Bowie, Ellen's 'In Case of Emergency' Episode: 143 Isabella Rossellini, Debbie Reynolds, Bill Rancic Episode: 144 Simon Baker, Cheri Oteri Episode: 145 Christopher Walken, Tim Meadows Episode: 146 Jennifer Garner, Jamie Kennedy Episode: 147 Dakota Fanning, Rebecca Romijn, Feline Reunion Episode: 148 Bill Cosby, Sarah Chalke Episode: 149 Mary Tyler Moore, Rosie Perez, Hidden Talents Episode: 150 Jay Leno, Lorraine Bracco Episode: 151 Lindsay Lohan, Kevin Sorbo, Ending of ‘Friends’ Episode: 152 Hugh Jackman, Al Roker, Car Giveaway Episode: 153 Josh Duhamel, Christina Ricci Episode: 154 David Schwimmer from ‘Friends,’ Gabrielle Union Episode: 155 Patti LaBelle, Cynthia Nixon Episode: 156 Usher, Patrick Stewart, Cooking with Nigella Lawson Episode: 157 Paula Abdul, Wilmer Valderrama Episode: 158 David Spade, Latoya London, Vanessa Marcil Episode: 159 Simon Cowell, Jorja Fox Episode: 160 Dolly Parton, Jon Favreau, Workout Attire Episode: 161 Glenn Close, Andy Richter Episode: 162 Jake Gyllenhaal, Sean Hayes, 8-Year-Old Drummer Episode: 163 Antonio Banderas, Alanis Morissette Episode: 164 Cameron Diaz, Cotton Candy Episode: 165 Halle Berry, Tom Selleck Episode: 166 Kate Hudson, Julian McMahon Episode: 167 Justin Timberlake, Sharon Stone, Fantasia Barrino